Abstract
Angiostrongylus cantonensis was first discovered in 1934 by Professor Chen Xintao and has become an important emerging pathogen causing human angiostrongyliasis. Rats are permissive host, and mice and human are non-permissive host. The adult worms live in the right ventricle and pulmonary arteries of rats. However, worms can’t develop to adult worm and the IV and V stage worm live in brain of mice and human. Human infect this disease by eating raw or undercooked snails or slugs, paratenic host such as prawns or contaminated vegetables, and water that contain the infective larvae. A. cantonensis has spread from its traditional endemic regions of the Pacific islands and Southeast Asia to the American continent including the USA, Caribbean islands, and Brazil. During the past few years, major outbreaks of human angiostrongyliasis have been reported in mainland China, Taiwan, Thailand, Ecuadorian, French, Germany, India, and Jamaica. Additionally, sporadic cases in travelers who have returned from endemic areas have been reported. Thousands of cases of human angiostrongyliasis have been documented worldwide. The main clinical manifestations of human angiostrongyliasis are eosinophilic meningitis and ocular angiostrongyliasis. In adult patients, the common symptoms were headache, neck stiffness, paresthesia, vomiting, and nausea. The treatment of this disease includes supportive treatment, corticosteroid therapy, and combined therapy with corticosteroids and anthelminthics. However, it is pity that some patients have sequela after treated. Therefore, some new drugs like Chinese herbal medicine have been studied for therapy angiostrongyliasis. The basic research is very important for better solution of angiostrongyliasis, so more and more study are in process, which involve mechanism of brain inflammation, new drugs finding, protein and gene sequence and analysis, new diagnosis method exploring, etc. Whatever, persuading people not to eat raw or undercooked intermediate and paratenic hosts is the most effective method for prevention and control angiostrongyliasis.
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References
Bessarab IN, Joshua GW (1997) Stage-specific gene expression in Angiostrongylus cantonensis: characterisation and expression of an adult-specific gene. Mol Biochem Parasitol 88:73–84
Bhaibulaya M (1975) Comparative studies on the life history of Angiostrongylus mackerrasae Bhaibulaya, 1968 and Angiostrongylus cantonensis (Chen, 1935). Int J Parasitol 5:7–20
Chau TT, Thwaites GE, Chuong LV, Sinh DX, Farrar JJ (2003) Headache and confusion: the dangers of a raw snail supper. Lancet 361:1866
Chen HT (1935) Un nouveau nematoda pulmonaire: Pulmonema cantonensis, n.g.n. sp. des rats de Canton. Ann Parasitol Hum Comp 13:312–317
Chen WL, Zhong JM, Chen H, Wu SY, Ding L (2006) Eosinophilic meningitis: 31 cases report. Chin J Misdiagnostics 6:4668–4669
Chen MX, Zhang RL, Chen JX, Chen SH, Li XH, Gao ST, Geng YJ, Huang DN, Ai L, Xu MJ, Zhu XQ (2010) Monoclonal antibodies against excretory/secretory antigens of Angiostrongylus cantonensis. Hybridoma 29:447–452
Chen D, Zhang Y, Shen H, Wei Y, Huang D, Tan Q, Lan X, Li Q, Chen Z, Li Z, Ou L, Suen H, Ding X, Luo X, Li X, Zhan X (2011a) Epidemiological survey of Angiostrongylus cantonensis in the west-central region of Guangdong Province, China. Parasitol Res 109:305–314
Chen F, Chen SR, Li KR, Li TH, Fang W, Luo JJ (2011b) Investigation on outbreak of Angiostrongyliasis cantonensis due to consumption of snail food in Dali City. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 23:687–690 (Article in Chinese)
Chen MX, Ai L, Xu MJ, Zhang RL, Chen SH, Zhang YN, Guo J, Cai YC, Tian LG, Zhang LL, Zhu XQ, Chen JX (2011c) Angiostrongylus cantonensis: identification and characterization of microRNAs in male and female adults. Exp Parasitol 128:116–120
Cheng M, Yang X, Li Z, He H, Qu Z, He A, Wu Z, Zhan X (2012) Cloning and characterization of a novel cathepsin B-like cysteine proteinase from Angiostrongylus cantonensis. Parasitol Res 110:2413–2422
Chotmongkol V, Sawanyawisuth K (2002) Clinical manifestations and outcome of patients with severe eosinophilic meningoencephalitis presumably caused by Angiostrongylus cantonensis. Southeast Asian J Trop Med Public Health 33:231–234
Chotmongkol V, Sawanyawisuth K, Thavornpitak Y (2000) Corticosteroid treatment of eosinophilic meningitis. Clin Infect Dis 31:660–662
Chotmongkol V, Sawadpanitch K, Sawanyawisuth K, Louhawilai S, Limpawattana P (2006) Treatment of eosinophilic meningitis with a combination of prednisolone and mebendazole. Am J Trop Med Hyg 74:1122–1124
Chuang CC, Su KE, Chen CW, Fan CK, Lin FK, Chen YS, Du WY (2010) Anti-CCR3 monoclonal antibody inhibits eosinophil infiltration in Angiostrongylus cantonensis-infected ICR mice. Acta Trop 113:209–213
Chye SM, Lin SR, Chen YL, Chung LY, Yen CM (2004) Immuno-PCR for detection of antigen to Angiostrongylus cantonensis circulating fifth-stage worms. Clin Chem 50:51–57
Cross JH (1978) Clinical manifestations and laboratory diagnosis of eosinophilic meningitis syndrome associated with angiostrongyliasis. Southeast Asian J Trop Med Public Health 9:161–170
Cross JH, Chen ER (2007) Angiostrongyliasis. In: Murrell KD, Fried B (eds) Food-borne parasitic zoonoses. Springer, New York, NY, pp 263–290
Deng ZH, Lv S, Lin JY, Lin RX, Pei FQ (2011) An outbreak of angiostrongyliasis in Guanging, People’s Republic of China: migrants vulnerable to an emerging disease. Southeast Asian J Trop Med Public Health 42:1047–1053
Diao Z, Wang J, Qi H, Li X, Zheng X, Yin C (2011) Human ocular angiostrongyliasis: a literature review. Trop Doct 41:76–78
Dorta-Contreras AJ, Padilla-Docal B, Moreira JM, Robles LM, Aroca JM, Alarcón F, Bu-Coifiu-Fanego R (2011) Neuroimmunological findings of Angiostrongylus cantonensis meningitis in Ecuadorian patients. Arq Neuropsiquiatr 69:466–469
Eamsobhana P, Tungtrongchitr A (2005) Angiostrongyliasis in Thailand. In: Arizono N, Chai JY, Nawa Y, Takahashi Y (eds) Food-borne helminthiasis in Asia, vol 1, Asian parasitology. The Federation of Asian Parasitologists, Chiba, Japan, pp 183–197
Eamsobhana P, Yong HS (2009) Immunological diagnosis of human angiostrongyliasis due to Angiostrongylus cantonensis (Nematoda:Angiostrongylidae). Int J Infect Dis 13:425–430
Fang W, Xu S, Wang Y, Ni F, Zhang S, Liu J, Chen X, Luo D (2010) ES proteins analysis of Angiostrongylus cantonensis: products of the potential parasitism genes? Parasitol Res 106:1027–1032
Fernando RL (2001) Angiostronglyosis. In: Fernando RL (ed) Tropical infectious diseases. Greenwich Medical Media, London, pp 107–110
Gu JB, Liu M, Li H, Luo YL, Li XX, Chen XG, Zhan XM (2008) Construction of the life cycle of Angiostrongylus cantonensis in laboratory. Nan Fang Yi Ke Da Xue Xue Bao 28:551–554 (Article in Chinese)
Han YP, Li ZY, Li BC, Sun X, Zhu CC, Ling XT, Zheng HQ, Wu ZD, Lv ZY (2011) Molecular cloning and characterization of a cathepsin B from Angiostrongylus cantonensis. Parasitol Res 109:369–378
Hasbun R, Abrahams J, Jekel J, Quagliarello VJ (2001) Computed tomography of the head before lumbar puncture in adults with suspected meningitis. N Engl J Med 345:1727–1733
He JZ, Zhu SH, Yang SQ, Yu BW, Chen YS, Hu GX, Wang SB, Wang L (1984) First discover and evidence of Angiostrongylus cantonensis in the cerebrospina fluid from the case of the population of the mainland of China. Acad J Guangzhou Med Coll 12:56–61 (Article in Chinese)
He ZY, Jia L, Huang F, Liu GR, Li J, Dou XF, Wang QY, He X, Gao ZY, Yang P, Wu J (2007) Survey on the outbreak of human angiostrongyliasis in Beijing. Chin J Public Health 23:1241–1242 (Article in Chinese)
He H, Cheng M, Yang X, Meng J, He A, Zheng X, Li Z, Guo P, Pan Z, Zhan X (2009) Preliminary molecular characterization of the human pathogen Angiostrongylus cantonensis. BMC Mol Biol 10:97
He HJ, Lv ZY, Li ZY, Zhang LY, Liao Q, Zheng HQ, Su WY, Rao SQ, Yu XB, Wu ZD (2011) Efficacy of combined treatment with albendazole and baicalein against eosinophilic meningitis induced by Angiostrongylus cantonensis in mice. J Helminthol 85:92–99
Hu X, Li JH, Lan L, Wu FF, Zhang EP, Song ZM, Huang HC, Luo FJ, Pan CW, Tan F (2012) In vitro study of the effects of Angiostrongylus cantonensis larvae extracts on apoptosis and dysfunction in the blood-brain barrier (BBB). PLoS One 7:e32161
Huang DN, Chen MX, Geng YJ, Li XH, Gao ST, Zhang RL (2010) Detection of circulating antigen of Angiostrongylus cantonensis by 12D5 and 21B7 monoclonal antibodies. Chin J Epidemiol 31:79–82
Intapan PM, Kittimongkolma S, Niwattayakul K, Sawanyawisuth K, Maleewong WJ (2008) Cerebrospinal fluid cytokine responses in human eosinophilic meningitis associated with angiostrongyliasis. Neurol Sci 267:17–21
Jin E, Ma D, Liang Y, Ji A, Gan S (2005) MRI findings of eosinophilic myelomeningoencephalitis due to Angiostrongylus cantonensis. Clin Radiol 60:242–250
Jitpimolmard S, Sawanyawisuth K, Morakote N, Vejjajiva A, Puntumetakul M, Sanchaisuriya K, Tassaneeyakul W, Tassaneeyakul W, Korwanich N (2007) Albendazole therapy for eosinophilic meningitis caused by Angiostrongylus cantonensis. Parasitol Res 100:1293–1296
Kliks MM, Palumbo NE (1992) Eosinophilic meningitis beyond the Pacific Basin: the global dispersal of a peridomestic zoonosis caused by Angiostrongylus cantonensis, the nematode lungworm of rats. Soc Sci Med 34:199–212
Lai SC (2006) Chinese herbal medicine Yin-Chen-Extract as an adjunct to anthelmintic albendazole used against Angiostrongylus cantonensis-induced eosinophilic meningitis or meningoencephalitis. Am J Trop Med Hyg 75:556–562
Lai SC, Chen KM, Chang YH, Lee HH (2008) Comparative efficacies of albendazole and the Chinese herbal medicine long-dan-xie-gan-tan, used alone or in combination, in the treatment of experimental eosinophilic meningitis induced by Angiostrongylus cantonensis. Ann Trop Med Parasitol 102:143–150
Li DN, He A, Wang Y, Liang Y, Li ZY, Men JX, Zhan XM (2001) Three lethal cases of Angiostrongylus cantonensis infected children. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 19:310–311 (Article in Chinese)
Li ZY, Lv ZY, Wei J, Liao Q, Zheng HQ, Wu ZD (2012a) Cloning and characterization of a novel gene encoding 16 kDa protein (Ac16) from Angiostrongylus cantonensis. Parasitol Res 110:2145–2153
Li ZY, Sun R, Li J, Song YX, Lin YC, Zeng X, He HJ, Wei J, Yang F, Zheng HQ, Lv ZY, Wu ZD (2012b) Efficacy of albendazole combined with a marine fungal extract (m2-9) against Angiostrongylus cantonensis-induced meningitis in mice. J Helminthol 86:410–417
Lin W, Wang XT (2004) Epidemiology of Angiostrongylus cantonensis in mainland. Chin J Zoonoses 20:1004–1007 (Article in Chinese)
Lin JX, Li YS, Zhu K, Chen BJ, Cheng YZ, Lin JC, Cao Y, Chen RZ (2003) Epidemiological study on group infection of Angiostrongylus cantonensis in Changle City. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 21:110–112 (Article in Chinese)
Lindo JF, Waugh C, Hall J, Cunningham-Myrie C, Ashley D, Eberhard ML, Sullivan JJ, Bishop HS, Robinson DG, Holtz T, Robinson RD (2002) Enzootic Angiostrongylus cantonensis in rats and snails after an outbreak of human eosinophilic meningitis, Jamaica. Emerg Infect Dis 8:324–326
Lindo JF, Escoffery CT, Reid B, Codrington G, Cunningham-Myrie C, Eberhard ML (2004) Fatal autochthonous eosinophilic meningitis in a Jamaican child caused by Angiostrongylus cantonensis. Am J Trop Med Hyg 70:425–428
Liu YH, Han YP, Li ZY, Wei J, He HJ, Xu CZ, Zheng HQ, Zhan XM, Wu ZD, Lv ZY (2010) Molecular cloning and characterization of cystatin, a cysteine protease inhibitor, from Angiostrongylus cantonensis. Parasitol Res 107:915–922
Liu Q, Yang X, Zhang M, Wang L, Liu J, Chen J, He A, Li Z, Wu Z, Zhan X (2012) Molecular characterization and immunolocalization of a protein disulfide isomerase from Angiostrongylus cantonensis. Parasitol Res 110:2501–2507
Liu LH, He HJ, Lv ZY, Wei J, Zeng X, Liang JY, Zheng HQ, Yu XB, Sun X, Wu ZD (2013) The mRNA level of the galectin-10 of Angiostrongylus cantonensis induced by reactive oxygen stress. Parasitol Res 112:933–943
Lo RV III, Gluckman SJ (2003) Eosinophilic meningitis. Am J Med 114:217–223
Luessi F, Sollors J, Torzewski M, Muller HD, Siegel E, Blum J, Sommer C, Vogt T, Thomke F (2009) Eosinophilic meningitis due to Angiostrongylus cantonensis in Germany. J Travel Med 16:292–294
Lv S, Zhang Y, Steinmann P, Zhou XN (2008) Emerging angiostrongyliasis in mainland China. Emerg Infect Dis 14:161–164
Lv S, Zhang Y, Chen SR, Wang LB, Fang W, Chen F, Jiang JY, Li YL, Du ZW, Zhou XN (2009a) Human angiostrongyliasis outbreak in Dali, China. PLoS Negl Trop Dis 3:e520
Lv S, Zhang Y, Liu HX, Hu L, Yang K, Steinmann P, Chen Z, Wang LY, Utzinger J, Zhou XN (2009b) Invasive snails and an emerging infectious disease: results from the first national survey on Angiostrongylus cantonensis in China. PLoS Negl Trop Dis 3:e368
Lv S, Zhang Y, Liu HX, Zhang CW, Steinmann P, Zhou XN, Utzinger J (2009c) Angiostrongylus cantonensis: morphological and behavioral investigation within the freshwater snail Pomacea canaliculata. Parasitol Res 104:1351–1359
Maizels RM, Yazdanbakhsh M (2003) Immune regulation by helminth parasites: cellular and molecular mechanisms. Nat Rev Immunol 3:733–744
Maleewong W, Sombatsawat P, Intapan PM, Wongkham C, Chotmongkol V (2001) Immunoblot evaluation of the specificity of the 29-kDa antigen from young adult female worms Angiostrongylus cantonensis for immunodiagnosis of human angiostrongyliasis. Asian Pac J Allergy Immunol 19:267–273
Malvy D, Ezzedine K, Receveur MC, Pistone T, Crevon L, Lemardeley P, Josse R (2008) Cluster of eosinophilic meningitis attributable to Angiostrongylus cantonensis infection in French policemen troop returning from the Pacific Islands. Travel Med Infect Dis 6:301–304
Mattis A, Mowatt L, Lue A, Lindo J, Vaughan H (2009) Ocular angiostrongyliasis-first case report from Jamaica. West Indian Med J 58:383–385
Morera P, Céspedes R (1970) Angiostrongylus costaricensis n.sp. (Nematoda: Metastrongyloidea), a new lungworm occurring in man in CostaRica. Rev Biol Trop 18:173–185
Nuamtanong S (1996) The evaluation of the 29 and 31 kDa antigens in female Angiostrongylus cantonensis for serodiagnosis of human angiostrongyliasis. Southeast Asian J Trop Med Public Health 27:291–296
Ogawa K, Kishi M, Ogawa T, Wakata N, Kinoshita M (1998) A case of eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis with unique brain MRI findings. Rinsho Shinkeigaku 38:22–26 (Article in Japanese)
OuYang L, Wei J, Wu Z, Zeng X, Li Y, Jia Y, Ma Y, Zhan M, Lei W (2012) Differences of larval development and pathological changes in permissive and nonpermissive rodent hosts for Angiostrongylus cantonensis infection. Parasitol Res 111:1547–1557
Pascual Gispert JE, Aguilar Prieto PH, Galvez Oviedo MD (1981) Finding of Angiostrongylus cantonensis in the cerebrospinal fluid of a boy with eosinophilic meningoencephalitis. Rev Cubana Med Trop 33:92–95
Paul A, Pammal AT (2008) Ocular parasitosis: a rare cause of hypertensive uveitis. Indian J Ophthalmol 56:501–502
Peng H, Sun R, Zhang Q, Zhao J, Wei J, Zeng X, Zheng H, Wu Z (2013) Interleukin 33 mediates type 2 immunity and inflammation in the central nervous system of mice infected with Angiostrongylus cantonensis. J Infect Dis 207:860–869
Punyagupta S, Bunnag T, Juttijudata P, Rosen L (1970) Eosinophilic meningitis in Thailand. Epidemiologic studies of 484 typical cases and the etiologic role of Angiostrongylus cantonensis. Am J Trop Med Hyg 19:950–958
Punyagupta S, Juttijudata P, Bunnag T (1975) Eosinophilic meningitis in Thailand. Clinical studies of 484 typical cases probably caused by Angiostrongylus cantonensis. Am J Trop Med Hyg 24:921–931
Qu ZY, Yang X, Cheng M, Lin YF, Liu XM, He A, Wu ZD, Zhan XM (2011) Enzootic angiostrongyliasis, Guangdong, China, 2008–2009. Emerg Infect Dis 17:1335–1336
Rosen L, Laigret J, Boils PL (1961) Observation on an outbreak of eosinophilic meningitis on Tahiti, French Polynesia. Am J Hyg 74:26–42
Rosen L, Chappell R, Laqueur GL et al (1962) Eosinophilic meningoencephalitis caused by a metastrongylid lung-worm of rats. JAMA 179:620–624
Rosen L, Loison G, Laigret J et al (1967) Studies on eosinophilic meningitis: 3, epidemiologic and clinical observations on Pacific islands and the possible etiologic role of Angiostrongylus cantonensis. Am J Epidemiol 85:17–44
Sawanyawisuth K, Kitthaweesin K (2008) Optic neuritis caused by intraocular angiostrongyliasis. Southeast Asian J Trop Med Public Health 39:1005–1007
Sawanyawisuth K, Kitthaweesin K, Limpawattana P, Intapan PM, Tiamkao S, Jitpimolmard S, Chotmongkol V (2006) Intraocular angiostrongyliasis: clinical findings, treatments and outcomes. Trans R Soc Trop Med Hyg 101:497–501
Sawanyawisuth K, Takahashi K, Hoshuyama T, Sawanyawisuth K, Senthong V, Limpawattana P, Intapan PM, Wilson D, Tiamkao S, Jitpimolmard S, Chotmongkol V (2009) Clinical factors predictive of encephalitis caused by Angiostrongylus cantonensis. Am J Trop Med Hyg 81:698–701
Schmutzhard E, Boongird P, Vejjajiva A (1988) Eosinophilic meningitis and radiculomyelitis in Thailand, caused by CNS invasion of Gnathostoma spinigerum and Angiostrongylus cantonensis. J Neurol Neurosurg Psychiatry 51:80–87
Shih PC, Lee HH, Lai SC, Chen KM, Jiang ST, Chen YF, Shiow SJ (2007) Efficacy of curcumin therapy against Angiostrongylus cantonensis-induced eosinophilic meningitis. J Helminthol 81:1–5
Sinawat S, Sanguansak T, Angkawinijwong T, Ratanapakorn T, Intapan PM, Yospaiboon Y (2008) Ocular angiostrongyliasis: clinical study of three cases. Eye (Lond) 22:1446–1448
Slom TJ, Cortese MM, Gerber SI, Jones RC, Holtz TH, Lopez AS, Zambrano CH, Sufit RL, Sakolvaree Y, Chaicumpa W, Herwaldt BL, Johnson S (2002) An outbreak of eosinophilic meningitis caused by Angiostrongylus cantonensis in travelers returning from the Caribbean. N Engl J Med 346:668–675
Sonakul D (1978) Pathological findings in four cases of human angiostrongyliasis. Southeast Asian J Trop Med Public Health 9:220–227
Sugaya H, Aoki M, Abe T, Ishida K, Yoshimura K (1997) Cytokine responses in mice infected with Angiostrongylus cantonensis. Parasitol Res 83:10–15
Sun R, Li ZY, He HJ, Wei J, Wang J, Zhang QX, Zhao J, Zhan XM, Wu ZD (2012) Molecular cloning and characterization of a matrix metalloproteinase, from Caenorhabditis elegans: employed to identify homologous protein from Angiostrongylus cantonensis. Parasitol Res 110:2001–2012
Tsai HC, Liu YC, Kunin CM, Lee SS, Chen YS, Lin HH, Tsai TH, Lin WR, Huang CK, Yen MY, Yen CM (2001a) Eosinophilic meningitis caused by Angiostrongylus cantonensis: report of 17 cases. Am J Med 111:109–114
Tsai TH, Liu YC, Wann SR, Lin WR, Lee SJ, Lin HH, Chen YS, Yen MY, Yen CM (2001b) An outbreak of meningitis caused by Angiostrongylus cantonensis in Kaohsiung. J Microbiol Immunol Infect 34:50–56
Vazquez JJ, Boils PL, Sola JJ, Carbonell F, de Juan Burgueño M, Giner V, Berenguer-Lapuerta J (1993) Angiostrongyliasis in a European patient: a rare cause of gangrenous ischemic enterocolitis. Gastroenterology 105:1544–1549
Wan KS, Weng WC (2004) Eosinophilic meningitis in a child raising snails as pets. Acta Trop 90:51–53
Wang QP, Chen XG, Lun ZR (2007) Invasive freshwater snail, China. Emerg Infect Dis 13:1119–1120
Wang QP, Lai DH, Zhu XQ, Chen XG, Lun ZR (2008) Human angiostrongyliasis. Lancet Infect Dis 8:621–630
Wang H, Qiu H, Qiu JB (2010) The research progress of angiostrongyliasis spread and prevalence. Exp Lab Med 28:377–378
Wang QP, Wu ZD, Wei J, Owen RL, Lun ZR (2012) Human Angiostrongylus cantonensis: an update. Eur J Clin Microbiol Infect Dis 31:389–395
Wang J, Wei J, Zeng X, Liang JY, Wu F, Li ZY, Zheng HQ, He HJ, Wu ZD (2013) Efficacy of tribendimidine against Angiostrongylus cantonensis infection in the mice. Parasitol Res 112:1039–1046
Wei J, Wu F, Sun X, Zeng X, Liang JY, Zheng HQ, Yu XB, Zhang KX, Wu ZD (2013) Differences in microglia activation between rats-derived cell and mice-derived cell after stimulating by soluble antigen of IV larva from Angiostrongylus cantonensis in vitro. Parasitol Res 112:207–214
Xue DY, Ruan YZ, Lin BC, Zheng RY, Fang JQ, Zhao QX, Li MF, Pan CW (2000) Epidemiological investigation on an outbreak of Angiostrongyliasis cantonensis in Wenzhou. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 18:176–178 (Article in Chinese)
Yang FZ, Zhang YZ, Tu ZP, Xu LS (2004) Survey on the outbreak of human angiostrongyliasis caused by eating snails. Strait J Prev Med 10:44–45 (Article in Chinese)
Yang X, Qu Z, He H, Zheng X, He A, Wu Y, Liu Q, Zhang D, Wu Z, Li Z, Zhan X (2012) Enzootic angiostrongyliasis in Guangzhou, China, 2008–2010. Am J Trop Med Hyg 86:846–849
Ye DG, Luo B, Liu BD, Zheng P (2008) Epidemiological study of Angiostronglus cantonensis infection in Fuzhou City. J Trop Med 8:938–940
Yii CY (1976) Clinical observations on eosinophilic meningitis and meningoencephalitis caused by Angiostrongylus cantonensis on Taiwan. Am J Trop Med Hyg 25:233–249
Zhang RL, Chen MX, Gao ST, Geng YJ, Huang DN, Liu JP, Wu YL, Zhu XQ (2008) Enzootic angiostrongyliasis in Shenzhen, China. Emerg Infect Dis 14:1995–1996
Zheng RY, Jin R, Lin BC, Pan CW, Xue DY (2001) Probing and demonstrating etiological factors for outbreak of Angiostrongyliasis cantonensis in Wenzhou. Shanghai J Prev Med 13:105–107
Zhou Z, Barennes H, Zhou N, Ding L, Zhu YH, Strobel M (2009) Two outbreaks of eosinophilic meningitis in Yunann (China) clinical, epidemiological and therapeutical issues. Bull Soc Pathol Exot 102(2):75–80 [Article in French]
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Wei, J., Wu, Z. (2014). Angiostrongylus cantonensis in China. In: Mehlhorn, H., Wu, Z., Ye, B. (eds) Treatment of Human Parasitosis in Traditional Chinese Medicine. Parasitology Research Monographs, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39824-7_14
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