Trikoramide
A, a Prenylated Cyanobactin from the Marine
Cyanobacterium Symploca hydnoides
Posted on 2019-11-25 - 14:18
A new cyclic decapeptide, trikoramide A (1), has been
isolated from samples of the marine cyanobacterium Symploca
hydnoides, collected from Bintan Island, Indonesia. Trikoramide
A (1) is a C-prenylated cyclotryptophan-containing cyanobactin.
Its planar structure was deduced by 1D and 2D NMR spectroscopy as
well as HR–MS/MS data. In addition, its absolute configuration
was determined by Marfey’s method and 2D NOESY NMR spectroscopic
analysis. Compound 1 possessed cytotoxicity against the
MOLT-4 and AML2 cancer cell lines with IC50 values of 4.8
and 8.2 μM, respectively.
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Phyo, Ma Yadanar; Ding, Chi Ying Gary; Goh, Hui Chin; Goh, Jun Xian; Ong, Ji Fa Marshall; Chan, Siew Herng; et al. (2019). Trikoramide
A, a Prenylated Cyanobactin from the Marine
Cyanobacterium Symploca hydnoides. ACS Publications. Collection. https://doi.org/10.1021/acs.jnatprod.9b00675
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AUTHORS (9)
MP
Ma Yadanar Phyo
CD
Chi Ying Gary Ding
HG
Hui Chin Goh
JG
Jun Xian Goh
JO
Ji Fa Marshall Ong
SC
Siew Herng Chan
PY
Pui Yi Maria Yung
HC
Hartono Candra
LT
Lik Tong Tan
KEYWORDS
TrikoramideHRCompound 1sample2 D NOESY NMR spectroscopic analysisBintan Islandtrikoramidemarine cyanobacterium Symploca hydnoidesdata4.81 D8.2 μ MIC 50 values2 D NMR spectroscopyPrenylated Cyanobactincyclic decapeptideC-prenylated cyclotryptophan-containing cyanobactinMarfeyconfigurationMarine Cyanobacterium Symploca hydnoidescytotoxicitymethodMOLT -4AML 2 cancer cell lines