Symplostatin 1:  A Dolastatin 10
Analogue from the Marine
Cyanobacterium Symploca hydnoides

Valeriote, Fred A.

Symplostatin 1: A Dolastatin 10 Analogue from the Marine Cyanobacterium Symploca hydnoides

Posted on 1998-09-11 - 00:00

A new solid tumor selective cytotoxic analogue of dolastatin 10 (1) has been isolated from the marine cyanobacterium Symploca hydnoides, collected near Guam. This metabolite has been assigned the trivial name symplostatin 1 (2). This discovery supports the proposal that many compounds isolated from the seahare Dolabella auricularia, the original source of the dolastatins, are of dietary origin.

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Harrigan, George G.; Luesch, Hendrik; Yoshida, Wesley Y.; Moore, Richard E.; Nagle, Dale G.; Paul, Valerie J.; et al. (2016). Symplostatin 1: A Dolastatin 10 Analogue from the Marine Cyanobacterium Symploca hydnoides. ACS Publications. Collection. https://doi.org/10.1021/np980321c

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